Isolation of Iridoid Glycoside from Fraxinus griffithii Clarke Leaves

Kartini, Kartini and ., Sutarjadi and ., Indah (2011) Isolation of Iridoid Glycoside from Fraxinus griffithii Clarke Leaves. In: International Seminar on Medicinal Chemistry and Timmerman Award 2011, 15 October 2011, Surabaya.

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Abstract

Development of new and has relatively less side-effect anti-seizure is important for pharmacist. To answer this issue, research to isolate iridoide glycoside from ethanol extract of the cortex and leaves of Fraxinus griffithii Clarke (tiken) has been conducted. Pharmacological screening test showed that those extract have anti-seizure activity on mice. It was conducted with electroshock method. Quantitative analysis with Trim-Hill reagent showed that the concentration of total iridoid of tiken leaves is higher than its cortex, 2.12% and 0.55% AE (Aucubin Equivalent), respectively. Isolation of iridoid glycosides from tiken cortex and leaves was done on an open column using silica gel as stationary phase and CHCL3-Methanol (47:3) as mobile phase. Identification of isolate from cortex (isolate X) and leaves (isolate Z) was done with three different TLC systems and used anisaldehid-H2SO4 (vanillin-H2SO4) as spray reagent. Each isolate showed a red-brown and red-purple spot. Spectrum of isolate X in methanol showed a maximum wavelength at 277.8 and 223.4 nm, whereas isolate Z at 278 and 223 nm.

Item Type:	Conference or Workshop Item (Paper)
Uncontrolled Keywords:	iridoid glycoside, Fraxinus griffithii, anti-seizure
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Karyono
Date Deposited:	12 Oct 2012 06:50
Last Modified:	03 Mar 2020 03:18
URI:	http://repository.ubaya.ac.id/id/eprint/1176

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