Studi Komparatif Konsentrasi Pengikat HPMC 2, 3 dan 5 terhadap Karakteristik Fisik Tablet Kitosan Metode Granulasi Basah

GUNAWAN, TEDDY (2012) Studi Komparatif Konsentrasi Pengikat HPMC 2, 3 dan 5 terhadap Karakteristik Fisik Tablet Kitosan Metode Granulasi Basah. [Undergraduate thesis]

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Official URL: http://digilib.ubaya.ac.id/pustaka.php/227937

Abstract

A Research was conducted to analyze the influence of concentration of HPMC as a binder against the physical characteristics of chitosan tablets in the manufacture of tablets using wet granulation method. Concentration of binder added is 2%, 3% and 5%. There were three formulas to be evaluated: Formula 1, Formula 2, and Formula 3. The evaluation of the physical characteristics of tablets was based on the uniformity of weight, uniformity of size, hardness, friability, and disintegration time. The result of evaluation from Formula 1, 2, and 3 was conformed with qualifies of characteristics tablet. The results of the physical characteristics of tablets were analyzed statistically by One-way ANOVA with a significant level of 5%. The statistical analyzed showed that uniformity of size, uniformity of weight, and disintegration time, there were significant differences between Formula 1, 2, and 3 whereas, friability and hardness showed no significant difference.

Item Type: Undergraduate thesis
Uncontrolled Keywords: HPMC, kitosan, tablet, pengikat, granulasi basah
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Moch. Ali Syamsudin 197011
Date Deposited: 28 Apr 2014 01:59
Last Modified: 28 Apr 2014 01:59
URI: http://repository.ubaya.ac.id/id/eprint/12022

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