Development of Standardized Ethanol Extract of Fraxinus Griffithii as CNS Depressant

., Kartini and ., Sutarjadi and Kirtishanti, AgusIina and Kesuma, Dini and Soediman, Soediatmoko and Hendrajaya, Kusuma (2011) Development of Standardized Ethanol Extract of Fraxinus Griffithii as CNS Depressant. Journal of US-China Medical Science, 8 (10). pp. 617-625. ISSN 1548-6648

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Background: Fraxinus griffithii has been widely used as CNS depressant. Its activity based on both empirical and preclinical data. However, standardization on raw material and process of extraction have not been conducted. Methods: Extraction of Fraxinus griffithii was conducted on different part of plants, as well as different solvents and extraction methods. Each extract was standardized both on specific and nonspecific parameters. Additionally, phenobarbital induced sleeping time test was performed on each extract. Results: Leaves of F. griffithii extracted with 70% ethanol by kinetic maceration yielded the highest extract. CNS depressant activity of 70% ethanol extract obtained from F. griffithii leaves by kinetic maceration was the highest compared to the others. Conclusion: All of the extracts have CNS depressant activity, but extract from the leaves, produced by 70% ethanol and kinetic maceration had the optimal activity and quality.

Item Type: Article
Uncontrolled Keywords: Fraxinus griffithii, standardized, phenobarbital induced sleeping time test, CNS depressant.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 19 Mar 2012 07:20
Last Modified: 09 Jun 2017 08:29

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