PERANAN ERDOSTEIN DALAM PERBAIKAN GEJALA KLINIS PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK

Raharjo, Dian Natasya and Setiabudi, Irwan and Setiadi, Antonius Adji Prayitno and ., Santoso (2015) PERANAN ERDOSTEIN DALAM PERBAIKAN GEJALA KLINIS PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK. Jurnal Ilmiah Sains & Teknologi, 8 (2). pp. 13-20. ISSN 0216-1540

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Abstract

Background. Any exposure to oxidant agents from cigarettes and air pollutants will lead to lung inflammation and worsen the condition in patients with Chronic Obstructive Pulmonary Disease (COPD). The presence of antioxidants, such as erdosteine, required to inhibit the oxidative stress therefore it can improve the clinical symptoms in patients with COPD. Aim. To analyze the improvement of symptoms in COPD patients who received erdosteine as an additional therapy compared with COPD patients who only receive the regular therapy. Methods. The subjects were divided into two randomized groups, regular therapy group (control) and regular therapy group with additional erdosteine (test). Observations made during the 10 days, the subjects answered a questionnaire about their clinical symptoms. Results. A total of 27 subjects were included in the control group and 25 in the test group. In the control group, after 10 days, the value of the pre-test and post-test differ significantly in symptom scores (p = 0.000; CI 95%), as well as the value of the test group. The value improvement were analyzed by comparing the delta score between pre-test and post-test. It showed a better improvement in the test group (p = 0.040; 95% CI). Conclusion. The addition of erdosteine to regular COPD therapy provide better improvement of clinical symptoms in COPD patients. Keywords: erdosteine, COPD, clinical symptoms

Item Type: Article
Uncontrolled Keywords: erdosteine, COPD, clinical symptoms
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: DIAN NATASYA R - 210004
Date Deposited: 16 Jun 2016 02:32
Last Modified: 15 Dec 2016 02:33
URI: http://repository.ubaya.ac.id/id/eprint/27947

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