Synthesis and activity evaluation of a novel lead compound 1-benzyl-3-benzoylurea as antiproliferative agent

Suhud, Farida and ., Siwandono and Budiati, Tutuk (2015) Synthesis and activity evaluation of a novel lead compound 1-benzyl-3-benzoylurea as antiproliferative agent. world Journal of Pharmaceutical Sciences, 3 (2). ISSN 2321-3086

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Official URL: http://goo.gl/VyrOyM

Abstract

This research deals with designing and synthesizing a novel lead compound 1-benzyl-3-benzoylurea using the modified Schotten Baumann method and the objective is to find a more potent drug.In order to achieve the goal , the in-silico activity againts 1-UWH was calculated by Molegro Virtual Docker. Then, in-vitro antiproliferative activity against MCF-7 cell line was tested by MTT assay and compared with Hydroxyurea as a reference compound. The result showed that both in-silico and in-vitro test of 1-benzyl-3-benzoylurea were more potent than Hydroxyurea. It is highly recommended that 1-benzyl-3-benzoylurea be developed further as an antiproliferative agent.

Item Type: Article
Uncontrolled Keywords: 1 - benzyl - 3 - benzoylurea, designing, synthesizing, antiproliferative activity
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 18 Jul 2016 10:16
Last Modified: 18 Jul 2016 10:16
URI: http://repository.ubaya.ac.id/id/eprint/28086

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