Uji Aktivitas In-silico Senyawa Baru 1-Benzil-3-benzoilurea Induk dan Tersubstitusi sebagai Agen Antiproliferatif

Suhud, Farida (2015) Uji Aktivitas In-silico Senyawa Baru 1-Benzil-3-benzoilurea Induk dan Tersubstitusi sebagai Agen Antiproliferatif. Jurnal Farmasi Indonesia, 7 (4). pp. 245-251. ISSN 1412-1107

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Abstract

This study deals with designing and molecular docking a novel lead compound 1- benzyl-3-benzoylurea and the substituted compounds as antiproliferative agents. The objective of this study was predicting a more potent antiproliferative agent In order to achieve the goal , the in-silica activity againts 1-UWH receptor was calculated by Molegro Virtual Docker 5 and compared with Hydroxyurea as a reference compound. The result showed that all lead and substituted compounds of 1-benzyl-3-benzoylurea were more potent than Hydroxyurea. It is highly recommended that all lead and substituted compounds of 1-benzyl-3-benzoylurea be synthesized further as antiproliferative agents.

Item Type: Article
Uncontrolled Keywords: 1-benzyl-3-benzoylurea, designing, molecular docking, antiproliferative agents
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 18 Jul 2016 10:44
Last Modified: 05 Oct 2016 02:33
URI: http://repository.ubaya.ac.id/id/eprint/28088

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