The effect of Cl substituent position in benzoylchloride reagent towards the yield of synthesis of the novel lead and substituted compounds of 1-benzoyl-3-benzylurea as prospective anticancers

Suhud, Farida (2015) The effect of Cl substituent position in benzoylchloride reagent towards the yield of synthesis of the novel lead and substituted compounds of 1-benzoyl-3-benzylurea as prospective anticancers. Proceeding International Conference On Natural Mathematical and Environmental Sciences for Sustainable Development (names 2015). ISSN 2461-0968

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Abstract

This study is related to design and syntllesize of a novel lead compound 1-benzoyl-3-benzylurea and the compounds which are subtituted with Cl substituent, as prospective anticancers with antiproliferation mechanism. The purpose of this study is to obtain a novel lead compound 1-benzoyl-3-benzylurea and the compounds which are subtituted with Cl substituent at a different posisition. In order to reach such purpose, the synthesis with nucleopilic substitution reaction and modified Schotten Baumann method was done. Benzylurea as a starting material is reacted with the lead and subtituted benzoylchloride reagents {2-CI, 3-CI and 4-CI). Four compounds are yielded from the synthesis, which are 1-benzoyl-3-benzylurea 36%, 1-benzoyl-3-(2- chlorobenzyl)urea 8%, 1-benzoyl-3-(3-chlorobenzyl)urea 22% and 1-benzoyl-3-(4-chlorobenzyl)urea 36%. The position of substituent towards the carbonyl group affects the compound's electropilic force. The closer the substituent to the carbonyl group, the less the electrophilic force is. Due to the fact that the synthesis yields are relatively low, it is highly recommended to do further optimation in synthesis to all of the lead and substituted compounds 1-benzoyl-3-benzylurea as prospective anticancers.

Item Type: Article
Uncontrolled Keywords: the lead and substituted compounds 1-benzoyl-3-benzylurea, design, synthesize
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 18 Jul 2016 11:27
Last Modified: 18 Jul 2016 11:27
URI: http://repository.ubaya.ac.id/id/eprint/28090

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