FORMULAI FLOATING TABLET MENGGUNAKAN VARIASI KONSENTRASI HPMCK100M TERHADAP KEMAMPUAN MENGAPUNG DAN PROFIL DISOLUSI TABLET RANITIDINE HCL

Pradana, Aditya Trias and Parfati, Nani and Shira, Shallyn Aprillia (2015) FORMULAI FLOATING TABLET MENGGUNAKAN VARIASI KONSENTRASI HPMCK100M TERHADAP KEMAMPUAN MENGAPUNG DAN PROFIL DISOLUSI TABLET RANITIDINE HCL. Jurnal Ilmiah Sains & Teknologi, 9 (1). pp. 11-21. ISSN 0216-1540

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Abstract

In this study, a sustained release floating tablet formula is designed with Ranitidine HCl as a model drug. The aim of this study is to obtain the optimum concentration of HPMC K100M as the primary gelling polymer for floating tablet. This sustained release floating tablet is supposed to decrease release rate of the drug, thereby it prolong the gastric residence time. Tablets were prepared by direct compression technique, and the tablet weight uniformity, hardness, friability, assay of the active ingredient, floating lag time, floating duration time, and the drug release through dissolution test for 12 hours in 0,1 N HCl media were evaluated. The result showed the entire formula take less than 1 minute to buoyant, and are able to remain for more than 12 hours. Otherwise, dissolution efficiency (%ED) was significantly decreased with the addition of HPMC K100M F1 15%, F2 20%, F3 25%, and F4 30% were 90,56%; 84,05%; 77,47%; and 73,57% respectively.

Item Type: Article
Uncontrolled Keywords: HPMC, floating tablet, sustained release, Ranitidine HCl
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 06 Sep 2016 03:23
Last Modified: 06 Sep 2016 08:55
URI: http://repository.ubaya.ac.id/id/eprint/28356

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