Ekspresi dan Kadar GABA pada Palatum Sekunder Mencit Prenatal dengan Paparan Diazepam di Periode Organogenesis

Yulia, Rika and ., Kuntoro and Santoso, Heru and Darmanto, Win (2015) Ekspresi dan Kadar GABA pada Palatum Sekunder Mencit Prenatal dengan Paparan Diazepam di Periode Organogenesis. Jurnal Farmasi Indonesia, 7 (4). pp. 228-232. ISSN 1412-1107

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Abstract

This study aimed to analyze changes in expression and levels of Gamma-aminobutyric acid (GABA) neurotransmitters in the palate of prenatal mice exposed to diazepam in the period of organogenesis. GABA is required in palate formation. About 27 mices (Mus musculus) of known age and weight were used. They were divided in three groups, i.e. control group which were injected daily with distilled water, the second groups were injected daily with diazepam 8 mg/kg/day and the third groups were injected daily with diazepam 16 mg/kg/day. All groups were administered intraperitoneally injection during the organogenesis phase (9th – 15th days). Increased GABA level significantly shown in treated groups. The result showed that the exposure of diazepam during the period of organogenesis cause increased of GABA level.

Item Type: Article
Uncontrolled Keywords: Cleft palate, organogenesis, diazepam, GABA, prenatal mice
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 25 Oct 2016 05:45
Last Modified: 25 Oct 2016 05:48
URI: http://repository.ubaya.ac.id/id/eprint/28539

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