PLATELET AGGREGATION PROFILE AND CARDIOVASCULAR EVENT IN CORONARY HEART DISEASE PATIENTS WITH DUAL ANTIPLATELET

Rochmawati, Ike Dhiah and Parfati, Nani and Manda, Edlin and ., Carollina (2016) PLATELET AGGREGATION PROFILE AND CARDIOVASCULAR EVENT IN CORONARY HEART DISEASE PATIENTS WITH DUAL ANTIPLATELET. Proceedings 2nd Indonesian Conference on Clinical Pharmacy, 9 (6). p. 101. ISSN 2455-3891

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Abstract

Platelet aggregation plays an important role in atherosclerosis process in Coronary Heart Disease (CHD) patients. Antiplatelet acts to prevent platelet aggregation and thrombus subsequently. Thrombus will block artery coronaries. Antiplatelet responsiveness can be seen by aggregation platelet profile. Based on the background, the aim of this research was to review platelet aggregation and cardiovascular event profile in CHD patients with dual antiplatelet. Prospective study was used in this study. CHD patients with dual antiplatelet therapy, willing to follow this research, and compliance with therapy were recruited into this study. Blood samples from patients were collected for platelet aggregation test. Platelet aggregation was analyzed by Light Aggregometry which used three platelet inducer (ADP, Collagen, Epinephrine). Cardiovascular event was defined by ischemic attack that CHD patients got in 3 months. 12 patients were recruited for this research. From the 12 patients, 5 patients occured ischemic attack within follow up. Platelet aggregation for that 5 patients which had ischemic attack, was normal and under normal platelet aggregation. Platelet activation is contributor subsequent atherothrombosis in patients with high inflammatory regulations in artery wall and systemic circulation. Platelet aggregation profile can be reflected as antiplatelet activity. Statistical analysis was done for aggregation profile and cardiovascular event. P-values > 0.05 which means there’s no correlation between platelet aggregation and cardiovascular event. Platelet aggregation in this research showed in normal and under

Item Type: Article
Uncontrolled Keywords: Platelet aggregation, Antiplatelet, Cardiovascular event
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: IKE DHIAH ROCHMAWATI
Date Deposited: 18 Apr 2017 03:42
Last Modified: 18 Apr 2017 07:23
URI: http://repository.ubaya.ac.id/id/eprint/29582

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