Effects of Plantago major extracts and its chemical compounds on proliferation of cancer cells and cytokines production of lipopolysaccharide-activated THP-1 macrophages

., Kartini and Piyaviriyakul, Suratsawadee and Thongpraditchote, Suchitra and Siripong, Pongpun and Vallisuta, Omboon (2017) Effects of Plantago major extracts and its chemical compounds on proliferation of cancer cells and cytokines production of lipopolysaccharide-activated THP-1 macrophages. Pharmacognosy Magazine, 13 (51). pp. 393-399. ISSN ISSN: Print -0973-1296, Online - 0976-4062

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Abstract

Background: Plantago major has been reported to have anticancer and anti-inflammatory properties. However, its antiproliferative and anti-inflammatory mechanisms have not elucidated. Moreover, which plant parts are more suitable as starting materials has not been explored. Objectives: To investigate the antiproliferative activity of P. major MCF-7, MDA-MB-231, HeLaS3, A549, and KB cancer cell lines as well as their effects on inflammatory cytokines (tumor necrosis factor [TNF]-a, interleukin [IL]-1β, IL-6, an [IFN]-g) production by lipopolysaccharide (LPS)-stimulated THP-1 macrophages. Materials and Methods: The methanol and aqueous extracts of P. major from different plant its chemical compounds, i.e., ursolic acid (UA), oleanolic acid (OA), and aucubin were tested in this experiment. Results: Methanol and aqueous extracts of P. major greatest antiproliferative activity. The methanol extracts of seeds also demonstrated the highest inhibition of TNF-a, IL-1β, IL-6, and IFN-g production. Interestingly, t commonly discarded, exhibited comparable activities to those of leaves and petioles. Furthermore, UA exhibited stronger activities than OA and aucubin. Conclusions: being proposed as the main source for further development of anticancer and anti-inflammatory products, whereas the roots could be included in the preparation of products with respect to anti-inflammatory.

Item Type: Article
Uncontrolled Keywords: Anti-inflammatory, antiproliferative, cytokines, Plantago major, THP-1 macrophages
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Kartini
Date Deposited: 24 Jul 2017 06:02
Last Modified: 24 Jul 2017 06:02
URI: http://repository.ubaya.ac.id/id/eprint/30401

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