Wound healing activity of Plantago major extract on hyperglicaemic rat

., Kartini and lslamie, Ridho and Rambing, Christina Cicilia and Rahayu, Icha Bella Widya Siska (2017) Wound healing activity of Plantago major extract on hyperglicaemic rat. In: International Conference on Pharmacy Practice, 26-27 April 2017, Yogyakarta.

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Abstract

Impaired wound healing in diabetic patients is a serious complication that can lead to amputation and even death. Proper diabetic wound management is needed to improve the quality of life of diabetic patients. Plantago major (plantain) has been used empirically for wound healing. This study was conducted to determine the activity of ethanol extract of plantain on wound healing in hyperglycemic rats. A total of 30 hyperglicaemic male rats (Wistar) were divided into 6 groups (K1-K6), and subsequently treated with gel of ethanol extract of plantain leaves 5% and 10%, gel of ethanol extract of plantain roots 5% and 10 %, gel base, and bioplacenton®, respectively. Drugs were applied topically on animals’ wounds created on the dorsal part (length of 2 cm, a depth of 5 mm), once a day during 21 days. Wound healing activity was evaluated based on the percentage of wound closure and wound healing time. The results showed that the gel of ethanol extract of plantain leaves and roots at the concentration of 5% and 10% were able to increase the percentage of wound closure and accelerate wound healing time (p < 0.05) compared to the negative control. It can be concluded that the ethanol extract of plantain leaves and roots have wound healing activity on hyperglycemic rats.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Plantago major, plantain, ethanolic extract wound healing, Hyperglicemic
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Kartini
Date Deposited: 10 Aug 2017 02:48
Last Modified: 10 Aug 2017 02:48
URI: http://repository.ubaya.ac.id/id/eprint/30558

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