Lorensia, Amelia and Yunita, Oeke and Kharismawan, Andreas (2015) Acute Lung Toxicity of Juice and Soup of Katuk (Sauropus androgynus) Leaves as Breastmilk Booster Related to Bronchiolitis Obliterans. In: 1st International seminar on Natural Resources Biotechnology: From Local to Global, 8 - 9 September 2015, Yogyakarta.
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Abstract
Sauropus androgynus (SA) (katuk) as a traditional medicine to supplement breast milk production, has been widely used by the people of Indonesia to improve and accelerate the production of breast milk (air susu ibu/ASI). However based on some research said katuk suspected to cause constrictive bronchiolitis obliterans because of toxin exposure. Some adverse events katuk leaves in some countries could reduce the sale value of katuk, either as food or food supplements in Indonesia, if not further investigated. Indonesian society can consume leaves katuk direct way in the form of salad or soup can be cooked in advance. Therefore in this study will be conducted in vivo toxicity tests on the leaves katuk originating from East Java, Indonesia, is given in the form of vegetable juice and stew katuk orally, in Wistar females.SA extract was separated into eight parts, namely 500, 1000, 3000, and 5000 mg/kg for jus and soup groups. After 14 days, each rat was observes in macroscopic and microscopic of the lung. Then, It analyzed with ANOVA. The administration of juice and soup of leaves SA don’t cause changes in the physical condition of the rats. And katuk (Sauropus androgynus) leaf juice cause significant differences in the results of macroscopic observation that lung volume as well as the results of microscopic observation that the bronchial lumen ratio between treatment groups katuk leaf juice 5000 mg / kg and negative controls. Katuk leaf soup (Sauropus androgynus) causes significant variations in the macroscopic conditions (lung volume) and microscopic (the size of the bronchial lumen) in female Wistar rats. Our results indicate that the toxic necrosis of SA is dose-independent. More evidence is needed to clarify the incidence of necrosis in chronic used.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Oeke Yunita, S.Si, M.Si. Apt (1161) |
| Date Deposited: | 23 Feb 2018 02:31 |
| Last Modified: | 24 Mar 2021 15:46 |
| URI: | http://repository.ubaya.ac.id/id/eprint/31724 |
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