Formulation of Floating Tablets As Captopril Delivery System Using Direct Compression Method

Parfati, Nani and Pradana, Aditya Trias and Edrick, Arnold and Gunawan, Ario Adhibrata (2017) Formulation of Floating Tablets As Captopril Delivery System Using Direct Compression Method. In: ASEAN PharmNET 2017, Grand Season Hotel, Kuala Lumpur November 21st - 22nd 2017, November 21st - 22nd 2017, Kuala Lumpur.

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Formulation of Floating Tablets As Captopril Delivery System Using Direct Compression Method Parfati N1, Pradana AT1, Edrick A1, Gunawan AA1 1Department of Pharmaceutics, College of Pharmacy, University of Surabaya, Surabaya, Indonesia KEYWORDS: HPMC, CMC-Na, ethyl cellulose, floating tablet, sustained release INTRODUCTION Captopril short elimination half life (2-3 hours) and good stability at pH 1,2 with its major absorption in the upper part of Gastro Intestinal Tract (GIT) was the reason of this drug formulated into sustained release floating tablets. OBJECTIVES This research was conducted in order to obtain several formulation and evaluate the physical characteristics, floating lag time and dissolution rate of the floating tablets. MATERIALS AND METHODS The captopril floating tablets produced by direct compression technique using combination of polymers (HPMC, ethyl cellulose and CMC-Na in different concentrations). Final each tablet weight was 240 mg. Sodium bicarbonate and citric acid used as gas generating agent. The gel forming agent, gas generating agent and another polymer were used to control their floating capability and drug dissolution rate profile. RESULTS The formulated tablets were evaluated for hardness, friability, weight variation, drug content uniformity, in vitro release and floating capability. The tablet floating capability evaluation were characterized by lag time and floating duration. All formula remains buoyant for more than 12 hours. The drug release evaluated for 12 hours using USP paddle-type II dissolution apparatus in a 900ml 0,1N HCl as dissolution medium. The dissolution efficiency of control tablets (Formula 1) was 90,98%. There was a significance difference compared to dissolution efficiency value of Formula 2 (2% CMC-Na), Formula 3 (4% CMC-Na), Formula 4 (6% CMC-Na), Formula 5 (10% Ethyl cellulose), Formula 6 (20% Ethyl cellulose), Formula 7 (30% Ethyl cellulose) as 86,35%, 83,88%, 80,35%, 81.25%, 75.81%, and 78.16%, respectively. CONCLUSION The result of this research indicates that tablet formulation with different in composition of the polymers (CMC-Na and Ethyl cellulose) meet the requirements of tablet physical characteristics. Different composition of polymer also affects the floating capability and dissolution rate of the tablets, which is important in consider floating tablet as captopril sustained release delivery system.

Item Type: Conference or Workshop Item (Speech)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Date Deposited: 03 Apr 2018 05:07
Last Modified: 06 Aug 2018 03:21

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