Wound healing activity of Plantago major extract and its chemical compound on hyperglycemic rats

Kartini, Kartini and Islamie, Ridho (2018) Wound healing activity of Plantago major extract and its chemical compound on hyperglycemic rats. In: Bromo Conference Symposium on Natural Product & Biodiversity, 11-12 July 2018, Kampus C Universitas Airlangga Surabaya.

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Background: Impaired wound healing in diabetic patients is a serious complication leading to amputation and even death. Proper diabetic wound management is required to improve the quality of life of diabetic patients. Plantago major (plantain) has been used empirically for wound healing. One of its chemical compounds, oleanolic acid (OA), has been studied on non hyperglycemic wound. Objective: This study was conducted to determine the wound healing activity of plantain and OA on hyperglycemic rats, as a model for diabetic wound. Methods: A total of 40 hyperglycemic male rats (Wistar) were divided into 8 groups, and subsequently treated with gel of ethanol extract of P. major leaves and roots, OA, gel base, and bioplacenton®. Drugs were applied topically on animals’ wounds induced on the dorsal part, once a day during 21 days. Wound healing activity was evaluated based on the percentage of wound closure and wound healing time. Results: The results showed that the gel of plantain leaves and roots extracts as well as OA were able to increase the percentage of wound closure (100%) compare to the negative control (83%). Moreover, gel of Plantain and OA accelerated wound healing time (15.8 and 10 days, respectively) compared to the negative control (24.4 days). Conclusion: Plantain extracts and OA can be used as drug candidates for diabetic wound healing.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Plantago major, oleanolic acid, diabetic wound, wound closure, healing time
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Kartini
Date Deposited: 20 Jul 2018 01:52
Last Modified: 24 Mar 2021 15:50
URI: http://repository.ubaya.ac.id/id/eprint/32718

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