Parfati, Nani and Rani, Karina Citra and Charles , Nathanael and Geovanny, Valencia (2018) Preparation And Evaluation Of Atenolol-Β-Cyclodextrin Orally Disintegrating Tablets Using Co-Process Crospovidone-Sodium Starch Glycolate. International Journal of Applied Pharmaceutics, 10 (5). pp. 190-194. ISSN 0975–7058
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Abstract
Objective: The aim of this current research was to formulate and analyze the characteristics of atenolol-p-cyclodextrin which using co-process crospovidone-sodium starch glycolate as the disintegrants. Evaluation which has been conducted on orally disintegrating tablets consist of wetting time, water absorption ratio, in vitro dispersion time, and dissolution. Methods: Inclusion complex of atenolol-p-cyclodextrin which were prepared using solvent evaporation method, then formulated using co-processed crospovidone-sodium starch glycolate 1:1 (formula 1) and 1 :2 (formula 2) into orally disintegrating tablets by direct compression technique. Orally disintegrating tablets of atenolol-P-cyclodextrin using a physical mixture of crospovidone-sodium starch glycolate 1:1 (formula 3), 1:2 (formula 4) was also prepared as a control. The prepared formulations (Fl-F4) were evaluated by several parameters such as wetting time, water absorption ratio, in vitro dispersion time, and dissolution. Results: Orally disintegrating tablets of atenolol P-cyclodextrin using co-processed crospovidone-sodium starch glycolate 1:1 (formula 1) showed shorter wetting time (53.53 ± 2.26 seconds) and in vitro dispersion time (47.44 ± 2.49 seconds) compare to the other formulas. Formula 1 also exhibited the highest dissolution efficiency compare to the formula which was used in the physical mixture. The results of this study also revealed that there was a high correlation between in vitro dispersion time and dissolution efficiency of atenolol-p-cyclodextrin orally disintegrating tablets. Conclusion: Orally disintegrating tablets of atenolol- P-cyclodextrin showed enhanced dissolution efficiency due to the presence of inclusion complex and co-processed crospovidonesodium starch glycolate. Formula 1 was found to be the best formula in this study. This formula effectively reduces in vitro dispersion time, hence the dissolution efficiency became higher.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Atenolol, orally disintegrating tablets, inclusion complex, co-processed,crospovidone, sodium starch glycolate. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Ester Sri W. 196039 |
| Date Deposited: | 06 Aug 2018 05:33 |
| Last Modified: | 08 Dec 2021 08:04 |
| URI: | http://repository.ubaya.ac.id/id/eprint/32880 |
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