Kohar, Indrajati (2001) Reduction of a-tocopherylquinone Model Compound With Various Reductant. Unitas, 9 (2). pp. 3-17. ISSN 0854-3097
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Abstract
In order to study the possibility of tranformation of a-tocopherylquinone (TQ) into a more oxidiseable compound and also to find out the recycling effect in the cells, an experiment was conducted by reducing the model compound 2-(3- hydroxy-3-methylbutyl)-3,5,6-trimethyl-1,4-benzoquinone (PQ) with various reductants. In the experiment it was shown that glutathione did not reduce PQ,nor NADH by itself, so the effective reductant in the NADH/FAD combination must have been FADH2. Thus there is a probability that in a biological system, the most probable reductant for TQ would be a flavin enzyme rather that ascorbic acid or glutathione. The non-physiological dithiothreitol was as effective as NADH/ FAD which is interesting because of its similarity to the physiologically important reduced lipoic acid. The reactivity of the various reductants used in this experiment decrease in the order of dithiothreitol ~ NADH/FAD (8/10) > sodium dithionite > NADH/FAD (2:10) > sodium ascorbate > ascorbic acid (Fig.8).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | a-tocopherylquinone, reduction, Vitamin E, oxidation product. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Perpustakaan UBAYA |
| Date Deposited: | 28 Nov 2011 08:48 |
| Last Modified: | 29 Nov 2011 06:41 |
| URI: | http://repository.ubaya.ac.id/id/eprint/33 |
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