Hartono, Frenky and Sidharta, Emilia and Karina, Lidya and Cahyadi, Hanny (2018) The Management of Hepatotoxicity due to Antituberculotic Theraphy in a Patient with Cerebral Tuberculosis: Case Report and Literature Review. In: FAPA 2018: The 27th Federation of Asian Pharmaceutical Association Congress, October 24-27, 2018, Manila,Philippines.
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Abstract
Hepatotoxicity is the main problem of antituberculotic treatment like isoniazid,rifampicin and pyrazinamide.We evaluate the outcomes of re-challenge for antituberculosis drug in order to manage hepatotoxicity due to antituberculotic therapy in a patient with cerebral tuberculosis.A female patient was diagnosed with cerebral tuberculosis and had been treated with 5 regimens of antituberculotic drug: isoniazid, rifampicin, pirazinamid, ethambutol,and streptomycin.After four days,the patient felt several adverse reactions such as abdominal discomfort,nausea,and vomiting.Following this,a liver function test was performed.The levels of SGOT and SGPT elevated 15 times higher cted on day than the normal upper limit,which also indicated antituberculotic drug induced hepatotoxicity.A sequential rechallenge method was performed to overcome this problem.The method was successful to manage hepatotoxicity induced by antituberculotic therapy.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Ester Sri W. 196039 |
| Date Deposited: | 11 Jan 2019 03:30 |
| Last Modified: | 11 Jan 2019 03:30 |
| URI: | http://repository.ubaya.ac.id/id/eprint/34102 |
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