THE EFFECTS OF EXPOSURE DURATION TO ELECTRONIC CIGARETTE SMOKE ON DIFFERENCES IN SUPEROXIDE DISMUTASE AND MALONDIALDEHYDE IN BLOOD OF WISTAR RATS

Suryadinata, Rivan Virlando and Wirjatmadi, Bambang and Adriani, Merryana and Sumarmi, Sri (2019) THE EFFECTS OF EXPOSURE DURATION TO ELECTRONIC CIGARETTE SMOKE ON DIFFERENCES IN SUPEROXIDE DISMUTASE AND MALONDIALDEHYDE IN BLOOD OF WISTAR RATS. International Journal of Current Pharmaceutical Research, 11 (3). pp. 13-16. ISSN 0975-7066

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Abstract

Objective: Exposure to electronic cigarette smoke causes an increase of free radicals. Physiologically, the body produces antioxidant superoxide dismutase to neutralize the free radicals. However, an excessive increase of the free radicals will result in an imbalance between the amount of free radicals and antioxidants. The free radicals in the body can trigger lipid peroxidation so that it will result in oxidative stress causing cell damage. Malondialdehyde increase is a marker of oxidative stress in the body. The aim of this research is to understand the changes and the relationship between levels of superoxide dismutase and malondialdehyde in the blood due to exposure to electronic cigarette smoke. Methods: This research is an experimental study using male Wistar rats as experimental animal models. In the study, the exposure to electronic cigarette smoke with different duration of administration was carried out. Next, blood samples were taken to check the levels of superoxide dismutase and malondialdehyde. Results: The results showed a difference in antioxidant levels between antioxidant Superoxide Dismutase and malondialdehyde (p<0.05). Meanwhile the relationship between the two groups showed a strong (r = 0.893) and significant (p = 0.000) relationship. Conclusion: The exposure to electronic cigarette smoke can reduce the level of antioxidant superoxide dismutase and increase the level of malondialdehyde in blood. In addition, changes in the levels of antioxidant superoxide dismutase and malondialdehyde had a strong and significant relationship.

Item Type: Article
Uncontrolled Keywords: Superoxide Dismutase, E-Cigarette, Malondialdehyde, Free Radical
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medical
Depositing User: Ester Sri W. 196039
Date Deposited: 29 May 2019 06:54
Last Modified: 29 May 2019 06:54
URI: http://repository.ubaya.ac.id/id/eprint/34839

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