THE EFFECT OF COMPOSITE COMPOSITION RATIO TO THE PHYSICAL CHARACTERISTICS AND THE RELEASE OF CIPROFLOXACIN FROM BOVINE HYDROXYAPATITE-CHITOSAN-CIPROFLOXACIN IMPLANT

Rani, Karina Citra and Imanto, Teguh and Primaharinastiti, Riesta and Hendradi, Esti (2018) THE EFFECT OF COMPOSITE COMPOSITION RATIO TO THE PHYSICAL CHARACTERISTICS AND THE RELEASE OF CIPROFLOXACIN FROM BOVINE HYDROXYAPATITE-CHITOSAN-CIPROFLOXACIN IMPLANT. In: Pharmaceutical Nanotechnology Conference 2018, 23-24 Agustus 2018, Ibis Styles Hotel Surabaya. (Submitted)

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Abstract

ABSTRACT Objective: The objective of this study was to determine the effect of composite composition ratio (Bovine Hydroxyapatite-chitosan) to the physical characteristics and the release of ciprofloxacin from Bovine Hydroxyapatite-chitosan-ciprofloxacin implant. Methods: Ciprofloxacin implants were prepared using four different composition of composite (Bovine Hydroxyapatite-chitosan) 20:80; 30:70; 40:60; and 70:30. The amount of ciprofloxacin in each pellet was 10%. Implants were formed into pellets with 4.0 mm diameters and weighed 100.0 mg using compression method. Further, the prepared ciprofloxacin implants were characterized for porosity, density, water absorption capacity, swelling ratio, disintegration test, compressive strength, compatibility studies (FT-IR), morphology (SEM), X-ray diffraction study, assay, and in vitro drug release. Results: The results obtained from this study revealed that composite composition ratio (Bovine Hydroxyapatite-chitosan) influenced the differences of physical characteristics and the release of ciprofloxacin from Bovine Hydroxyapatite-chitosan-ciprofloxacin implant. Increased of Bovine Hydroxyapatite ratio in composite composition caused enhancement of physical characteristics (porosity, density, water absorption capacity, and compressive strength) of the implant. Meanwhile, increased of Bovine Hydroxyapatite ratio in implant caused the release of ciprofloxacin became lower. Conclusion: The optimal composite composition ratio to produce Bovine Hydroxyapatite-chitosan-ciprofloxacin implant with desired physical characteristics and ciprofloxacin release was Bovine Hydroxyapatite-chitosan (70:30). Keywords: Ciprofloxacin, Bovine Hydroxyapatite, Chitosan, Composite, Implant

Item Type: Conference or Workshop Item (Speech)
Subjects: R Medicine > RZ Other systems of medicine
T Technology > TP Chemical technology
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: KARINA CITRA RANI
Date Deposited: 17 Jun 2019 04:37
Last Modified: 17 Jun 2019 04:37
URI: http://repository.ubaya.ac.id/id/eprint/34841

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