The Effectiveness of 2,4-Diklorobenzoiltiourea as Anticonvulsant with Electroshock Method in Mice

Kirtishanti, Aguslina and Kesuma, Dini (2011) The Effectiveness of 2,4-Diklorobenzoiltiourea as Anticonvulsant with Electroshock Method in Mice. In: International Seminar On Medical Chemistry And Timmerman Award 2011, October 15, 2011, Surabaya.

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2,4-diklorobenzOIItiourea is a derivative of benzoiluourea which has acyclictioureide group and similiar structure with barbiturate derivatives. Barbiturate and its derivatives have anticonvulsant effects. The objective of this study is to determine the anticonvulsant effect of 2,4 diklorobenzoiltiourea which is measured with electroshock. This is an experimental study using four groups of mice which consist of two experimental groups, one control group and one standard group. The first two groups were given 25 mg/kg and 50 mg/kg suspension of 2,4-diklorobenzoiltiourca for each group. The control group were given suspension of Sodium CMC and the standard group were given 26 mg/kg Sodium Phenobarbital. Thirty minutes after treatment, all the animals through their eyes were introduced with 0.5 mA electric shock for 0.2 second as seizure inducer. Effect of anticonvulsant were identified from the reducing duration of seizures which are total of either tonic, clonic and tonic-clonic seizures. The result the analysed statistically and showed that 2,4-diklorobenzoiltiourca has anticonvulsant effect and has similar strength with sodium phenobarbital.

Item Type: Conference or Workshop Item (Paper)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Ester Sri W. 196039
Date Deposited: 16 Aug 2019 05:31
Last Modified: 16 Jun 2023 05:56

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