Kirtishanti, Aguslina and Kesuma, Dini (2012) Identifikasi Efek Depresan Ssp (Susunan Saraf Pusat), Antikejang Dan Neurotoksisitas Senyawa 4-Klorobenzoiltiourea Pada Mencit Putih Jantan. Jurnal Teknosains, 2 (1). pp. 1-11. ISSN 9772089613006
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Abstract
The study of benzoylthiourea derivatives development as central nervous system (CNS) depressants were based on its structure which contains acyclic ureida group, an isosteric group of CNS depressant drugs common structure. The study approach is taken by modifying the structure of benzoylthiourea using Topliss model based on the enhancement of lipophilic and electronic properties, and the product is predicted to give higher activity than the parent compound. Identification of CNS depressant, anticonvulsant and neurotoxicity effects of the compound synthesized, 4-chlorobenzoylthiourea, was conducted. Identification of CNS depressant effects was done using Barbiturate Sleeping Time, while identification of anticonvulsant effects was done using Maximum Electroshock Seizure and neurotoxicity effect using rotarod in mice (Mus musculus). This study used five groups of mice: a control group, a standard group (Phenobarbital Na) and 3 treatment groups with the doses of 15 mg/kg, 45 mg/kg and 75 mg/kg respectively. From the results, it can be concluded that 4-chlorobenzoylthiourea gives the best CNS depressant, anticonvulsant, and neurotoxicity effects at the doses of 75 mg/kg, 15 mg/kg, and 45 mg/kg respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CNS depressant effect, anticonvulsant, neurotoxicity, 4-chlorobenzoylthiourea, Barbiturate Sleeping Time, Electroshock Seizure, Rotarod |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Ester Sri W. 196039 |
| Date Deposited: | 20 Aug 2019 07:26 |
| Last Modified: | 16 Jun 2023 05:47 |
| URI: | http://repository.ubaya.ac.id/id/eprint/35925 |
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