Furwanti, Cece (2020) Simultaneous HPLC determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product. Media Pharmaceutica Indonesiana. ISSN 1411-8734 (Submitted)
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Abstract
Introduction:Antihemoroid® suppository has been produced commercially by PT Kimia Farma, Indonesia. For QC purposes, a separated densitometric method for analysis of its active ingredients, lidocaine hydrochloride and hexachlorophene, was applied. Objective:The objective of this study was obtaining more efficient analysis method of LH and HC, therefore an HPLC procedure has been developed for the determination of both compounds simultaneously. Methods:AYMC-Triart C18 column was used with a gradient mobile phase consisting of acetonitrile and phosphate buffer 0.05 M (pH 6.0). Quantitative evaluation was performed at 220 nm. Method validation was performed according to the new methods of USP 41. Result: Showed that the HPLC method was simple, accurate, precise, and robust. Conclusion:The HPLC method can be applied in simultaneous determination of LH and HC in suppositories as a QC tool in the pharmaceutical industries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | hexachlorophene, HPLC, lidocaine HCl, method validation, suppository |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Postgraduate Programs > Master Program in Clinical Pharmacy |
| Depositing User: | Ester Sri W. 196039 |
| Date Deposited: | 13 Jan 2020 01:59 |
| Last Modified: | 13 Jan 2020 01:59 |
| URI: | http://repository.ubaya.ac.id/id/eprint/37017 |
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