Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases

Pradana, Krisnawan Andy and Anekson, Michael and Wahjudi, Mariana (2020) Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases. Immunological Investigations : A Journal of Molecular and Cellular Immunology, 49 (3). pp. 333-363. ISSN 0882-0139 (Print) 1532-4311 (Online)

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In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From the study, it is found that global diseases, like Crohn’s disease, rheumatoid arthritis, Graves’ disease, gelatin allergy, T1D, HIV, systemic lupus erythematosus, juvenile chronic arthritis, and Mycobacterial disease (tuberculosis and leprosy) suspected associated with the Indonesian HLA profiles.

Item Type: Article
Uncontrolled Keywords: HLA; Allele; Indonesia;global disease
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR180 Immunology
R Medicine > R Medicine (General)
Divisions: Faculty of Technobiology > Department of Biology
Date Deposited: 20 Jan 2020 03:09
Last Modified: 31 Mar 2020 13:45

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