Natallya, FR and Prakoeswa, CRS and Harnidya, D and Thohiroh, Anis (2018) The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy: A randomized control trial. Journal of Dermatological Treatment. ISSN 0954-6634
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Abstract
Background: Healing of chronic plantar ulcers in leprosy (CPUL) typically takes a long time due to impaired neurological function, thereby reducing the levels of growth factors and cytokines. Cytokines can be found in metabolite products from amniotic membrane stem cells. Chronic ulcers are frequently characterized by high levels of reactive oxygen species. Vitamin E (α-tocopherol) is widely used in skin lesions, owing to its antioxidant and antiinflammatory properties. Vitamin C also has antioxidant,antiinflammatory, and collagen synthesis properties useful in wound healing. Herein, we compared the effects of topical human amniotic membrane-mesenchymal stem cellconditioned medium (hAMMSC-CM) alone and with vitamins C and E on healing of CPUL. Methods: In this randomized controlled trial, topical agents were applied every 3 days for up to 8 weeks. Ulcer size, side effects, and possible complications were monitored weekly. Results: Healing percentage increased each week in all groups. Mean difference in ulcer size was the highest in the hAMMSC-CM+vitamin E group, implying better progress of wound healing. There were no side effects or complications. Conclusion: hAMMSC-CM+vitamin E is the best for healing of CPUL. Accepted ManuscriptKeywords: hAMMSC-CM, vitamin E, vitamin C, chronic plantar ulcers in leprosy
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | hAMMSC-CM,vitamin E, vitamin C, chronic plantar ulcersin leprosy |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | FRANSISKA RISMAULI NATALLYA |
| Date Deposited: | 21 Jan 2020 07:06 |
| Last Modified: | 24 Mar 2021 16:17 |
| URI: | http://repository.ubaya.ac.id/id/eprint/37096 |
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