Ruswanto, Ruswanto and Mardianingrum, Richa and Siswandono, Siswandono and Kesuma, Dini (2020) Reverse Docking, Molecular Docking, Absorption, Distribution, and Toxicity Prediction of Artemisinin as an Anti-diabetic Candidate. Molekul, 15 (2). pp. 88-96. ISSN 1907-9761 (print) , 2503-0310 (electronic)
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Abstract
Aldose reductase is an enzyme that catalyzes one of the steps in the sorbitol (polyol) pathway that is responsible for fructose formation from glucose. In diabetes, aldose reductase activity increases as the glucose concentration increases. The purpose of this research was to identify and develop the use of artemisinin as an anti-diabetic candidate through in silico studies, including reverse docking, receptor analysis, molecular docking, drug scan, absorption, and distributions and toxicity prediction of artemisinin. Based on the results, we conclude that artemisinin can be used as an anti-diabetic candidate through inhibition of aldose reductase.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aldose reductase, artemisinin, molecular docking, reverse docking |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Ester Sri W. 196039 |
| Date Deposited: | 27 Jul 2020 08:09 |
| Last Modified: | 24 Mar 2021 16:25 |
| URI: | http://repository.ubaya.ac.id/id/eprint/37931 |
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