Djawad, Khairuddin and Wahab, Siswanto and Wibisono, Olivia and Avanti, Christina and Putranti, Astridani R. and Bukhari, Agussalim and Patellong, Ilham J. i (2020) Protective Effect of Mangosteen Pericarp Extract Cream Against UVB-Induced Erythema. JCAD Journal of Clinical and Aesthetic Dermatology, 13 (10). E59-E65.
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Abstract
Background. Exposing the skin to ultraviolet B (UVB) radiation triggers inflammation, with erythema as the most prominent acute clinical manifestation. Xanthones, secondary metabolites of the mangosteen pericarp, have been shown to possess anti-inflammatory and antioxidant properties. With the increasing evidence of harmful effects of chemical sunscreens to marine organisms, it is necessary to develop environmentally friendly sunscreen options. Objective. We sought to assess the protective effect of a nano-liposomal mangosteen pericarp extract (MPE) cream against UVB-induced erythema. Methods. Thirty-one healthy subjects with Fitzpatrick Skin Types III or IV were enrolled.Six sites on the back of each volunteer were used for testing; Sites 1 to 4 were exposed to UVB at a dosage of two minimal erythema dose. Before UVB exposure, the test materials, including 5%, 10%, or 20% MPE cream, or a base cream without MPE, were applied to each site. Sites 5 and 6 served as the positive (UVB only, no treatment) and negative (no treatment, no UVB) control groups. The lightness index (?L*) and erythema index (?a*) were assessed before and 24 hours after treatment using Chromameter. Results. On all treated sites, there were only slight decrease of ?L* and increase of ?a*. The ?L* of the 5%, 10%, and 20% cream groups were 1.65, -0.4, and 0.01, respectively, which were significantly different from UVB group (4.53). The ?a* of the 5%, 10%, and 20% cream (1.03, -0.07; 0.16, respectively) was significantly different from the base cream (2.03) and UVB group (5.585). Conclusion. The 10% and 20% nano-liposomal cream of MPE appeared to exert protective effects against UVB-induced erythema on human skin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Chromameter, erythema, mangosteen pericarp extract, sunscreen, ultraviolet B |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Ester Sri W. 196039 |
| Date Deposited: | 04 Nov 2020 13:14 |
| Last Modified: | 24 Mar 2021 16:29 |
| URI: | http://repository.ubaya.ac.id/id/eprint/38409 |
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