Heterogeneity Of Triterpenes And Steroids Structure As DPP-4 Inhibitors: A Review Article

Budipramana, Krisyanti and Wirasutisna, Komar Ruslan and Wartono, Muhammad Widyo and Pramana, Yanatra Budi and Sukrasno, Sukrasno and Yuniarta, Tegar Achsendo (2021) Heterogeneity Of Triterpenes And Steroids Structure As DPP-4 Inhibitors: A Review Article. Rasayan Journal of Chemistry, 14 (1). pp. 149-154. ISSN 0974-1496; e-ISSN: 0976-0083

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Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitors are diabetes mellitus drugs that inhibit the metabolism of glucagonlike peptide-1 (GLP-1) from the DPP-4 enzyme thus prolong the half-life of GLP-1. This review provides an overview of DPP-4 inhibitors from triterpenes and steroids and some related compounds from in silico prediction, in vitro, and in vivo studies. The knowledge of the heterogeneity of DPP-4 inhibitors structure from synthetic drugs as well as natural sources will assist to design more potential DPP-4 inhibitors, yet it is needed to be evaluated clinically. Hopefully, the scientific combination among molecular modelling and experimental studies perspectives will generate DPP-4 inhibitors with the desired outcome.

Item Type:	Article
Uncontrolled Keywords:	Diabetes mellitus, DPP-4 Inhibitor, In-silico, In-vitro, Triterpenes, Steroids
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	KRISYANTI BUDIPRAMANA
Date Deposited:	02 Feb 2021 03:30
Last Modified:	01 Sep 2021 03:38
URI:	http://repository.ubaya.ac.id/id/eprint/38815

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