Identification of Phyllanthus niruri by FTIR spectroscopy with chemometrics

Kartini, Kartini and Hardianti, Devi and Hadiyat, Mochammad Arbi (2021) Identification of Phyllanthus niruri by FTIR spectroscopy with chemometrics. Pharmaciana, 11 (2). pp. 251-260. ISSN 2477 0256

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Phyllanthus niruri (Indonesian: meniran) is a crude drug used in scientific jamu for hyperuricemia, mild hypertension, osteoarthritis, hemorrhoids, and hypercholesterolemia. This plant contains various bioactive compounds such as flavonoids, terpenes, coumarins, lignans, tannins, saponins, alkaloids, etc. Phyllanthus niruri is a wild plant growing in the tropics and sub-tropics of Asia, America, and China. This herb grows well from the lowlands to the highlands, such as bushes, terrain, yards, roadsides, gardens, and rivers. The levels of active compounds in a plant can vary depending on many factors, such as growing location, temperature, humidity, rainfall, and others. This research aimed to evaluate and differentiate P. niruri herbs according to their geographical location using FTIR fingerprint coupled with chemometrics, Principal Component Analysis (PCA) and Cluster Analysis (CA). The results of this study showed that 14 samples of P. niruri are classified into two groups. The first group consists of P. niruri powder originating from Tawangmangu, Kediri, Surabaya, Bangkalan, Gresik, Mojokerto, Kertosono, Krian, Blitar, Nganjuk, unknown 1, unknown 2, and unknown 3, whereas the second group consists of only one sample from Pasuruan. In conclusion, FTIR fingerprint analyzed with chemometrics is adequate to differentiate the powder of P. niruri collected from different locations. FTIR fingerprints combined with chemometrics can be further considered as a method in the quality control process of P. niruri.

Item Type: Article
Uncontrolled Keywords: CA, chemometric, fingerprint, PCA, Phyllanthus niruri, quality control
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Kartini
Date Deposited: 04 Aug 2021 03:51
Last Modified: 27 Sep 2021 07:08

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