Acute toxicity study of the ethanolic extract of Eleutherine bulbosa Urb in Wistar rats

Wati, Helmina and Muthia, Rahmi and Kartini, Kartini and Setiawan, Finna (2021) Acute toxicity study of the ethanolic extract of Eleutherine bulbosa Urb in Wistar rats. Pharmacy Education, 21 (2). pp. 143-147. ISSN 1477-2701

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Abstract

Introduction: Eleutherine bulbosa Urb is a plant species with medicinal properties, including anti-inflammatory, widely relied upon in traditional practices. For this reason, the present research was intended to assess and, thus, ensure the safety of this plant for conventional medicinal purposes using a toxicity test study. Methods: The acute toxicity test of the ethanolic extract of E. bulbosa Urb (EEEB) used the method adopted from the Organization Economic Cooperation and Development (OECD) guidelines 425 for testing Wistar rats. Results: During 14 days of the acute toxicity study, there were no significant changes in rat weight, no mortality, and no signs of toxicity after the oral EEEB administration at 2000 mg/kg body weight (bw). The limit test showed that the LD50 of EEEB was higher than 2000 mg/kg bw. Conclusion: EEEB has low toxicity because its LD50 is higher than the limit test results.

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Kartini
Date Deposited:	09 Aug 2021 03:06
Last Modified:	24 Sep 2021 08:40
URI:	http://repository.ubaya.ac.id/id/eprint/39971

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