Novel Drug Delivery And Drug Targeting Recombinant Human Erythropoetin To Treat Anemia

Artika, Made Prita and Sawu, Sirilus Deodatus and Effendy, Ruliya Yunita and Nugraha, Aditya and Aprilia, Dini (2021) Novel Drug Delivery And Drug Targeting Recombinant Human Erythropoetin To Treat Anemia. World Journal of Pharmaceutical Research, 10 (11). pp. 1145-1151. ISSN 2277-7105

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Abstract

Recombinant Human erythropoietin (RhEpo) has become an important discovery in the medical world related to biological products. The discovery of RhEpo is very helpful in handling anemia conditions that caused by CKD, cancer patients undergoing chemotherapy, HIV and patient who lose a lot of blood after surgery. Anemia condition make the body cannot produce normally endogenous erythropoietin. Erythropoietin helps in proliferation, differentiation and maturation so they can increase of normal red blood cells. The erythropoietin gene was isolated and produced known as Recombinant Erythropoietin. RhEpo has poor stability so the administration still uses the parenteral route to preventing aggregation and denaturation. Other developments still carried out to optimization the gene of human erythroid cells. This could be an apportunity for find targets, drug selection and use of gene therapy for several diseases related to another blood disorders. Knowledge regarding the use of RhEpo will be very helpful to optimization of therapeutic effects.

Item Type:	Article
Uncontrolled Keywords:	Erythropoetin, RhEpo, Anemia
Subjects:	R Medicine > R Medicine (General)
Divisions:	Postgraduate Programs > Master Program in Clinical Pharmacy
Depositing User:	Made Prita Artika
Date Deposited:	03 Sep 2021 02:12
Last Modified:	03 Sep 2021 02:13
URI:	http://repository.ubaya.ac.id/id/eprint/40155

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