Development, Evaluation, and Molecular Docking of Oral Dissolving Film of Atenolol

Rani, Karina Citra and Parfati, Nani and Aryani, Ni Luh Dewi and Winantari, Agnes Nuniek and Pradana, Aditya Trias and Nawatila, Roisah and Putranti, Astridani Rizky and Irine, Florencia and Angelica, Florentia and Yohanes, Cintya and Avanti, Christina (2021) Development, Evaluation, and Molecular Docking of Oral Dissolving Film of Atenolol. Pharmaceutics, 13 (10). pp. 1-17. ISSN 1999-4923

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Abstract

The development of oral dissolving film (ODF) of atenolol is an attempt to enhance convenience and compliance for geriatric patients suffering from hypertension. Film former is the most es-sential component in ODF that determines the physical characteristic and drug release. In this study, three different types of film former including HPMC E5 4% (w/v), 5% (w/v), CMC-Na 3% (w/v), 4% (w/v), and Na-alginate 2.5% (w/v), 3% (w/v) were optimized in Formula 1 (F1) to Formula 6 (F6), respectively. A solvent casting method was employed to develop ODF of atenolol. The films formed by HPMC E5 produced a smooth and flexible surface, whereas CMC-Na and Na-alginate produced gritty textured films. Satisfactory results were obtained from several physical parameters such as film thickness, folding endurance, swelling index, and disintegration time. The homogeneity, drug content, and dissolution properties of ODF with HPMC exhibited better characteristics than the other formulas. Formula 1 exhibited the highest drug release compared to the other ODFs. The molecular docking results showed that there was a hydrogen bonding between atenolol and film formers which was also supported by the FTIR spectrum. The findings of this study suggest that HPMC E5 is the most favorable film former for ODF of atenolol.

Item Type:	Article
Uncontrolled Keywords:	oral dissolving film; atenolol; HPMC E5; CMC-Na; Na-alginate
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	KARINA CITRA RANI
Date Deposited:	22 Oct 2021 07:50
Last Modified:	25 Jun 2024 04:26
URI:	http://repository.ubaya.ac.id/id/eprint/40610

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