Discordance to ASHP Therapeutic Guidelines Increases the Risk of Surgical Site Infection

Herawati, Fauna and Yulia, Rika and Wijono, Heru and Massey, Firdaus Kabiru and Muliani, Nurlina and Kantono, Kevin and Soemantri, Diantha and Andrajati, Retnosari (2021) Discordance to ASHP Therapeutic Guidelines Increases the Risk of Surgical Site Infection. Pharmaceuticals, 14 (11). p. 1088.

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Official URL / DOI: https://www.mdpi.com/1424-8247/14/11/1088


Clean surgery without contamination does not require prophylactic antibiotics, but there are high-risk surgical procedures that may cause infection and/or involve vital organs such as the heart, brain, and lungs, and these indeed require the use of antibiotics. This study aimed to deter- mine the quantity of antibiotic use based on the defined daily dose (DDD) per 100 bed days and the quality of antibiotic use based on the percentage of concordance with The American Society of Health-System Pharmacists (ASHP) therapeutic guidelines (i.e., route of administration, time of ad- ministration, selection, dose, and duration). This includes the profiles of surgical site infection (SSI) in surgical patients from January through June 2019. The study subjects were 487 surgical patients from two hospitals who met the inclusion criteria. There were 322 patients out of 487 patients who had a clean surgical procedure. Ceftriaxone (J01DD04) was the most used antibiotic, with a total DDD/100 bed days value in hospitals A and B, respectively: pre-surgery: 14.71, 77.65, during sur- gery: 22.57, 87.31, and postsurgery: 38.34, 93.65. In addition, 35% of antibiotics were given more than 120 min before incision. The lowest concordance to ASHP therapeutic guideline in hospital A (17.6%) and B (1.9%) was antibiotic selection. Two patients experienced SSI with bacterial growths of Proteus spp., Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli. The usage of prophylactic antibiotics for surgical procedures was high and varied between hospitals. Hospital B had significantly lower concordance to antibiotic therapeutic guidelines, resulting to a higher infec- tion rate, compared with hospital A. ASHP adherence components were then further investigated, after which antibiotic dosing interval and injection time was found to be a significant predictor for positive bacterial growth based on logit–logistic regression. Further interventions and strategies to implement antibiotic stewardship is needed to improve antibiotic prescriptions and their use.

Item Type: Article
Uncontrolled Keywords: defined daily dose; surgical site infection; antibiotic stewardship; hospital
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Ester Sri W. 196039
Date Deposited: 28 Oct 2021 04:42
Last Modified: 28 Oct 2021 04:42
URI: http://repository.ubaya.ac.id/id/eprint/40647

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