In Vitro Antifungal Susceptibility Testing of Tea Tree Oil (TTO) 5% Compared with Nystatin against Candida sp. as Important Agent of Oral Candidiasis in HIV/AIDS Patients

Lydiawati, Eva and Listiawan, Muhammad Yulianto and Murtiastutik, Dwi and Rahmadewi, Rahmadewi and Prakoeswa, Cita Rosita Sigit and Avanti, Christina and Fitriani, Endang Wahyu and Triyono, Erwin Astha and Astari, Linda and Zulkarnain, Iskandar (2020) In Vitro Antifungal Susceptibility Testing of Tea Tree Oil (TTO) 5% Compared with Nystatin against Candida sp. as Important Agent of Oral Candidiasis in HIV/AIDS Patients. Berkala Ilmu Kesehatan Kulit dan Kelamin (BIKKK), 32 (3). pp. 189-194. ISSN 1978-4279

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Abstract

Background: Oral candidiasis is the most common clinical manifestation in a person infected with HIV which has been linked with the severity of the disease. Candida albicans responsible for most oral candidiasis. The increased resistance to the available antifungal drugs can reduce the efficacy of therapy. Therefore, it will be crucial to discover novel antifungal agents. One of them is tea tree oil (TTO) or Melaleuca alternifolia which has a potent antifungal effect to inhibit the growth of Candida sp. Purpose: To evaluate the antifungal susceptibility of TTO 5% compared with nystatin against Candida sp. taken from HIV/AIDS patients. Methods: The study assessed the antifungal effect of TTO 5% and nystatin against 33 isolates of Candida sp. that was isolated from the oral cavity of 30 HIV/AIDS patients in Dr. Soetomo General Academic Teaching Hospital Surabaya, Indonesia. Antifungal susceptibility was evaluated by the disc diffusion method. The diameter of the inhibition zone was determined as the result of this study. Result: The most strains found in this study was Candida albicans (84.8%). The mean inhibition zone of nystatin against all strains was 23.24 mm whether it was 17.55 mm for TTO 5%. The inhibition zone of both TTO 5% and nystatin in Candida non-albicans were tended to be higher than in Candida albicans. It revealed that the inhibition zone of TTO 5% significantly lower than nystatin (P = 0.00; P < 0.05).Conclusion: Therefore, the antifungal susceptibility of nystatin was significantly higher than TTO 5% against Candida albicans and non-albicans.

Item Type:	Article
Uncontrolled Keywords:	tea tree oil; Melaleuca alternifolia; nystatin; antifungal susceptibility testing; oral candidiasis; HIV/AIDS
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	07 Mar 2022 05:15
Last Modified:	07 Mar 2022 05:15
URI:	http://repository.ubaya.ac.id/id/eprint/41468

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