Kirtishanti, Aguslina (2012) The motor coordination disorder effect of 2-chlorobenzoylthiourea in mice. In: International Biology Conference, Science for Energy, Food and Environmental Sustainability, December 6th, 2012, lnstitut Teknologi Sepuluh Nopember - Surabaya.
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Abstract
Recently, stress and mental diseases has increased. The therapies used to treat them are drugs that suppress the central nervous system. To find a new drug that acts on the central nervous system, synthesis of a benzoylthiourea derivative containing acyclic ureide group similar to barbiturates has been conducted. This study used 2-chlorobenzoylthiourea, a benzoiltiourea derivative. The activity assays of 2-chlorobenzoylthiourea as central nervous system suppressant was carried out by observing the motor coordination disorder in mice on the rotarod apparatus. The study used treatment, standard, and control groups. The treatment group were given 2- chlorobenzoylthiourea in five dosage of 15 mg/kgBW, 30 mg/kgBW, 45 mg/kgBW, 60 mg/kgBW and 75 mg/kgBW; the standard group were given 36,4 mg/kgBW of Phenobarbital Na; and control group were given a 0,5% CMC-Na suspension. The mice were left for 60 minutes after the treatments, and then were put on a rotarod apparatus. The parameter measured was how long the mice were able to stay on the rotarod. The results of One-Way ANOVA statistical analysis showed a significant difference between the control group and the treatment and standard groups. There was no significant difference, neither between the treatment and the standard group nor between doses given in the treatment group, but the shortest average lasting time was obtained from the test compound at a dose of 15 mg/kgBW
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | 2-chlorobenzoylthiourea, motor coordination disorder, central nervous system suppressant, rotarod |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Ester Sri W. 196039 |
| Date Deposited: | 28 Mar 2022 09:23 |
| Last Modified: | 07 Oct 2022 03:04 |
| URI: | http://repository.ubaya.ac.id/id/eprint/41630 |
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