Studi in silico : Hubungan Kuantitatif Struktur-Aktivitas Antivirus SARS-COV2 Pada Senyawa Turunan N-4- benzoil-N’-(4-fluorofenil) tiourea

Nasyanka, Anindi Lupita and Ratnasari, Diah and Na’imah, Janatun and Kesuma, Dini (2022) Studi in silico : Hubungan Kuantitatif Struktur-Aktivitas Antivirus SARS-COV2 Pada Senyawa Turunan N-4- benzoil-N’-(4-fluorofenil) tiourea. Journal Syifa Sciences and Clinical Research (JSSCR), 4 (2). pp. 501-508. ISSN 2656-9612(Online); 2656-8187(Print)

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Abstract

Specific therapies for the SARS-CoV2 virus are still being developed in several countries countries in the world. One of the suspected molecular targets specific to SARS COV2 is the 3CLpro or main protease of the COVID-19 virus. Based on the target of this work, there are similarities between the compounds N-4-benzoyl-N'-(4-fluorophenyl)thiourea derivatives with their inhibitors. This study aims to develop derivative compounds N-4-benzoyl-N'-(4-fluorophenyl)thiourea as a potential drug candidate inhibiting SARS-CoV2 viral protein using the HKSA method in silicon. Based on the results of the analysis, the best equation for the development of anti-virus SARS-CoV2 was Log 1/C = 0.269 Log P2 – 2.776 Log P + 0.221 cMR +3.195 (n= 8; R = 0.949 S= 0.11399; F=12,119;Sig=0,018). The role of the lipophilic and -containing groups steric can increase its activity as an anti-virus SARS-CoV2 In silico on the modification of the derivative.

Item Type:	Article
Uncontrolled Keywords:	Covid-19, 3Clpro , HKSA, In silico, N-4-benzoIl-N’-(4-fluorofenil)tiourea
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	29 Jun 2022 08:04
Last Modified:	30 Mar 2023 05:22
URI:	http://repository.ubaya.ac.id/id/eprint/42027

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