Kajian Pustaka Kristal Cair (Cubosome) Sebagai Sistem Penghantaran Obat Nanopartikel

Putranti, Astridani Rizky and Winantari, Agnes Nuniek and Krisnadewi, Ni Made (2022) Kajian Pustaka Kristal Cair (Cubosome) Sebagai Sistem Penghantaran Obat Nanopartikel. MEDFARM: Jurnal Farmasi dan Kesehatan, 11 (1). pp. 101-114. ISSN 2715-9957; p-ISSN:2354-8487

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Abstract

Cubosomes are cubic lipid-based delivery systems that can be an option for compounds that have low solubility in water belonging to BCS grades II and IV. The aim of this literature review is to get distinctive characteristics of cubosomes and the entrapment efficiency. Cubosomes was made by lipid (phytantriol, GMO) and added with stabilizer using top-down or bottom-up method. Characterization of cubosomes with instrument such as cryo-TEM (morphology), SAXS (crystalinity), and DLS (size distribution, zeta potential). The characteristic results obtained are cubic with size distribution of 100-500 nm and zeta potential values ±17 mV to 30 mV. As for entrapment efficiency generated ± 90% which indicates most drugs can enter the system.

Item Type:	Article
Uncontrolled Keywords:	cubosomes, SAXS, cryo-TEM, DLS, entrapment efficiency
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	30 Jun 2022 09:13
Last Modified:	30 Mar 2023 05:18
URI:	http://repository.ubaya.ac.id/id/eprint/42036

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