The effect of Quinuclidine Derivatives, (s)-T1, (s)-T2, and (s)-T6, on Locomotor Activity in C57BL6 Mice

Nianpanich, Saranda and Islamie, Ridho and Sarasamkan, Jiradanai and Vajragupta, Opa and Rodsiri, Ratchanee (2022) The effect of Quinuclidine Derivatives, (s)-T1, (s)-T2, and (s)-T6, on Locomotor Activity in C57BL6 Mice. In: The Proceedings of The Joint Physiological Pharmacological Society Conference JPPSC-2022, 8-10 Juni 2022, Thailand.

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Abstract

Locomotor assessment is an important evaluation in the investigation of a new therapeutic drug. Changes in the locomotor function could be affecting other behavior assessments. Quinuclidine derivatives, (s)-T1, (s)-T2, and (s)-T6, selectively bind to the α3β4 nicotinic acetylcholine receptor (nAChR). The activation of the nicotinic receptor involved in locomotion changes in mice. This study aimed to determine the effect of (s)-T1, (s)-T2, and (s)-T6 on locomotor activity in C57BL6 mice. (s)-T1, (s)-T2, and (s)-T6 (1, 3, and 10 mg/kg) were injected subcutaneously. Locomotor activity was performed for 30 minutes in the open field test. Nicotine (0.5 mg/kg), a nAChR agonist, significantly decreased locomotion time, distance, and speed in the first 15 minutes. (s)-T2 (10 mg/kg) decreased locomotion time at 10 minutes after administration. (s)-T6 (10 mg/kg) also showed a significant decrease in the locomotion time and distance during 10 to 20 minutes after administration. (s)-T1 had no effect on locomotor activity. The results suggested that further behavioral studies using (s)-T2, and (s)-T6 should be performed 20 minutes after drug administration.

Item Type:	Conference or Workshop Item (Paper)
Uncontrolled Keywords:	Quinuclidine derivatives, α3β4 nicotinic acetylcholine receptor, locomotor activity
Subjects:	Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	28 Jul 2022 02:52
Last Modified:	30 Mar 2023 06:17
URI:	http://repository.ubaya.ac.id/id/eprint/42234

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