Effects of Maltodextrin on Sauropus androgynus Leaf Extract Characteristics

Yunita, Oeke and Winantari, Agnes Nuniek and Sugiarto, Ricky Permana and Prayitna, Gunawan Sutanto and Hwa, Lie (2022) Effects of Maltodextrin on Sauropus androgynus Leaf Extract Characteristics. Indonesian Journal of Pharmacy, 33 (3). pp. 455-464. ISSN 2338-9427; E-ISSN 2338-9486

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Abstract

Katuk (Sauropus androgynus) leaves are traditionally used in Indonesia to increase breast milk production in women. Because of the high moisture content, the leaf extract has been formulated into spray-dried extract powder. First, the freeze-dried leaves were extracted using ultrasonic-assisted extraction with 80% ethanol as the solvent. Second, the extract was spray- dried with maltodextrin as the drying aid and mixed with mannitol and crospovidone to improve the characteristics of the resultant powder. Then, the powder was evaluated by comparing its physical properties to those of the spray-dried S. androgynus extract, product X containing S. androgynus, and spray-dried lactose, including the angle of repose, bulk density, tapped density, true density, Hausner ratio, and moisture content. The results showed that formulating spray-dried S. androgynus extract into powder increased the particle size and produced better moisture content and flow, but some other properties still required improvements. After the powder formulation, thin-layer chromatography (TLC)-densitometry was conducted to analyze the samples’ metabolic profiles. The dried samples were each dissolved in a suitable solvent and then spotted on the GF254 plate with the mobile phase developed from n-butanol:acetic acid:water (60:22:1.2). Based on the TLC profiles (i.e., chromatograms) of S. androgynus leaves, freeze-dried leaves, the spray-dried extract, and extract powder, three different spots were observed clearly under the 366 nm UV light. Also, one spot at Rf 0.80 (S3) appearing in all the chromatograms indicated a stable chemical compound, i.e., unaffected by all factors in the entire S. androgynus powder formulations: from extraction to drying and formulation

Item Type:	Article
Uncontrolled Keywords:	densitometry, metabolic profiles, S. androgynus, spray-dried
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Oeke Yunita, S.Si, M.Si. Apt (1161)
Date Deposited:	07 Apr 2023 16:36
Last Modified:	28 Feb 2024 07:41
URI:	http://repository.ubaya.ac.id/id/eprint/43806

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