Pengembangan Mikrosfer Asiklovir Menggunakan Kitosan dan Natrium Tripolifosfat: Faktor Suhu Inlet

Muntu, Cynthia Marisca and Sadono, Sadono and Suwito, Melinda Natalia (2022) Pengembangan Mikrosfer Asiklovir Menggunakan Kitosan dan Natrium Tripolifosfat: Faktor Suhu Inlet. Keluwih: Jurnal Kesehatan dan Kedokteran, 4 (1). ISSN 2715-6419

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Abstract

Acyclovir is an antiviral used for the treatment of herpes simplex but it's a short half-life, thereby increasing the administration frequency. To overcome this problem, the acyclovir microsphere system was created with chitosan and sodium tripolyphosphate (NTPP). The formulation used a spray drying method which is influenced by the inlet temperature. Three variations of the inlet temperature are given, i.e. 170 oC (M1), 180 oC (M2), and 190 oC (M3). Physicochemical characterization obtained the same results on the three microspheres. They showed the occurrence of cross-linking between chitosan and NTPP. The average particle sizes of M1, M2, and M3 microspheres were 8.52 μm, 8.92 μm, and 9.83 μm respectively. All microspheres' morphology was spherical with a rough surface. The moisture content of M1, M2, M3 microspheres were 6.63%, 5.49%, 4.63%, respectively. The swelling index of M1, M2, and M3 microspheres obtained from 0.5-4 hours were 143.11-258.86%, 167.26-239.61%, and 152.49-259.60%. The recovery of M1, M2, and M3 microspheres was 33.93%, 47.26%, and 35.09% respectively. The acyclovir encapsulation efficiency of M1, M2, and M3 microspheres were 115.32%, 117.14%, and 111.16% respectively. Dissolution testing showed all three microspheres have the potential for controlled drug delivery systems. The inlet temperature affects the microsphere characteristics and the best inlet temperature was 180 oC.

Item Type:	Article
Uncontrolled Keywords:	chitosan, inlet temperature, microspheres, sodium tripolyphospha
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	CYNTHIA MARISCA MUNTU
Date Deposited:	14 Apr 2023 01:58
Last Modified:	14 Apr 2023 01:58
URI:	http://repository.ubaya.ac.id/id/eprint/44005

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