Optimization of Sucrose and Propylene Glycol Concentration in the Formulation of Chewable Gummy Tablets of Moringa Leaf Extract (Moringa oleifera L.)

Rani, Karina Citra and Jayani, Nikmatul Ikhrom Eka and Setaratika, Maulidia and Dewi, Syalza mumpuni (2023) Optimization of Sucrose and Propylene Glycol Concentration in the Formulation of Chewable Gummy Tablets of Moringa Leaf Extract (Moringa oleifera L.). BIOEDUSCIENCE, 7 (1). pp. 73-87. ISSN 2614-154X, e-ISSN: 2614-1558

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Abstract

Background: Moringa leaves extract is promising to develop into nutraceutical products, especially a chewable gummy. The desirable characteristics of chewable gummies are soft, elastic, springy, and flexible. Gelatin is a widely used gelling agent that maintains gel structure during storage. The other ingredients determining the chewable gel structure are filler and plasticizer. This study aimed to assess the effect of sucrose and propylene glycol concentration on Moringa leaves extract-based chewable gummy. Methods: The pour method conducted the preparation of chewable gummy tablets. Factorial design study (22) was applied to analyze the effect of two factors herein, filler and plasticizer. Two concentration levels in each element, herein sucrose (30% and 35% concentration) and propylene glycol (2% and 4% concentration), on the physical characteristics of the gummy tablet. Results: The results of the factorial analysis showed that the increase in sucrose concentration would produce a longer dispersion time and lower swelling ratio. The increase in propylene glycol decreases the syneresis potency. The alteration of physical characteristics during 14 days of storage, particularly in dispersion time, swelling ratio, and syneresis percentage. Conclusions: Based on the results of feasible design space, sucrose concentration (30-35%) and propylene glycol concentration (2-4%) optimized in this study produce the desirable characteristics of chewable gummy.

Item Type:	Article
Uncontrolled Keywords:	Chewable Gummy; Moringa oleifera; Propylene Glycol; Sucrose
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	KARINA CITRA RANI
Date Deposited:	25 May 2023 10:22
Last Modified:	25 May 2023 10:22
URI:	http://repository.ubaya.ac.id/id/eprint/44206

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