Anti-inflammatory Potential of Mangosteen Pericarp Extract (Garcinia mangostana L.)

Karnadi, Auw Natasha Felicia and Kok, Tjie (2023) Anti-inflammatory Potential of Mangosteen Pericarp Extract (Garcinia mangostana L.). FITOFARMAKA: Jurnal Ilmiah Farmasi, 13 (1). pp. 42-49. ISSN 2087-9164, e-ISSN 2622-755X

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Abstract

Mangosteen pericarp (Garcinia mangostana L.) has been used as an active ingredient in numerous traditional medicine formulations. However, their function as an anti-inflammatory agent has yet to be fully understood. Macrophage migration inhibitory factor (MIF) is a mediator that is essential for the development of pro-inflammatory reactions. Hence, MIF activity is often associated with inflammatory diseases and its inhibition could therefore be used as an approach to assess the potential of a material as anti-inflammatory agent. In this study, MIF was exposed with mangosteen pericarp extracts in order to assess the possible anti-inflammatory effect of the extract. The type of mangosteen pericarp extract that possesses the greatest potential as MIF inhibitor and its IC50 value were determined. Based on the results, n-hexane extract of mangosteen pericarp possesses the activity as MIF inhibitor with an IC50 of 4.24 mg/L, and therefore could potentially be used as an anti-inflammatory agent.

Item Type:	Article
Uncontrolled Keywords:	Garcinia mangostana (L); Pericarp extract; Anti-inflammation; MIF
Subjects:	T Technology > T Technology (General)
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	Ester Sri W. 196039
Date Deposited:	06 Jul 2023 04:41
Last Modified:	06 Jul 2023 04:41
URI:	http://repository.ubaya.ac.id/id/eprint/44442

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