Is particulate or non-particulate steroid the determinant of periarticular injection efficacy for controlling postoperative TKR pain? Network meta-analysis

Chilmi, Mohammad Zaim and Sugianto, Julius Albert and Putra, Zainurrahman Kurnia and Hanum, Puri Safitri and Ulfa, Maria (2023) Is particulate or non-particulate steroid the determinant of periarticular injection efficacy for controlling postoperative TKR pain? Network meta-analysis. Journal of Orthopaedics, 43. pp. 11-16. ISSN 0972-978X

PDF Puri Safitri Hanum_particulate or non-particulate steroid.pdf Download (5MB)

Abstract

Purpose: Combining steroids for a periarticular injection (PAI) regiment has resulted in better pain control for postoperative TKR pain. Despite the available evidence, the most effective type of steroid for PAI still needs to be established. Network meta-analysis is conducted to analyze whether there is any difference in the effect of particulate compared to non-particulate periarticular steroid injection on post-TKR patients for pain control based on published literature. Method: This study is conducted following the PRISMA guideline. In general, studies assessing the efficacy of periarticular injection analgesia added with either particulate (Triamcinolone, methylprednisolone, or prednis- olone) or non-particulate (dexamethasone or betamethasone) steroid compared to the same regiment were analyzed. Results: Ten studies were finally included from the 108 identified papers through database searching. VAS reduction on POD1 is found to be similar in particulate (0,91; CI95%: 0,45-1,37) compared to non-particulate (0,81; CI95%: 0,34-1,28) (Fig. 2). The difference becomes wider and favors non-particulate POD3. Subgroup analysis based on each steroid type was conducted. A stark difference can be observed for each pair of steroids (particulate and non-particulate), resulting in a similar cumulative effect of particulate and non-particulate steroids and inconsistent result on POD1 compared to POD3. Conclusion: From the available evidence, we concluded that particulate or non-particulate steroid does not significantly affect post-TKR pain management. Instead, the specific type of steroid contributes more to post- operative VAS reduction. Levels of evidence: Level III.

Item Type:	Article
Uncontrolled Keywords:	Steroid; Periarticular injection; Total knee replacement; Pain
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medical
Depositing User:	Ester Sri W. 196039
Date Deposited:	10 Aug 2023 02:41
Last Modified:	10 Aug 2023 02:41
URI:	http://repository.ubaya.ac.id/id/eprint/44694

Actions (login required)

View Item