Effectiveness And Safety Of CYD-TDV Vaccine In Children

Edbert, Sonny and Salim, Hotimah Masdan (2023) Effectiveness And Safety Of CYD-TDV Vaccine In Children. Jurnal Kesehatan Tambusai, 4 (3). ISSN 2777- 0524; e-ISSN 2774 - 5848 (Submitted)

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Abstract

Dengue virus is classified as an arbovirus and its incidence rate continues to grow, especially in children in the last few years recorded by WHO. In the absence of specific therapy to treat dengue, prevention with vaccination is the right choice, especially for Asia and endemic regions such as Indonesia. Until now, the vaccine for dengue is only available in one commercial formulation (CYD-TDV) which has been licensed and developed by Sanofi Pasteur. The purpose of this study is to determine the effectiveness and safety of the CYD-TDV vaccine for children in endemic areas. The method used in this study is a literature search. Conducted meta-analyses and systematic reviews published between 2017 and 2020 identified in MEDLINE, especially in children based on inclusion and exclusion criteria. The results of this study showed that the CYD-TDV vaccine had a higher level of immunogenicity in the vaccinated test group compared to the control group. This higher immunogenicity indicates that the vaccine is able to stimulate the immune system to produce a strong response against the targeted viral infection. In addition, the finding that there was no significant difference in adverse events between the two groups suggests that the CYD-TDV vaccine is safe to use. Vaccine safety is of paramount importance in disease prevention efforts, especially in the pediatric population who are vulnerable to adverse effects and complications that may arise from immunization. These findings provide additional confidence that these vaccines can be relied upon in childhood immunization programs in endemic areas. The conclusion that the CYD-TDV vaccine is effective and safe has important implications for further vaccine development, especially for Asian regions such as Indonesia.

Item Type:	Article
Subjects:	L Education > L Education (General) Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Sonny Edbert
Date Deposited:	21 Aug 2023 03:53
Last Modified:	21 Aug 2023 04:48
URI:	http://repository.ubaya.ac.id/id/eprint/44784

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