Genetic Polymorphisms of Ischemic Stroke in Asians

Besin, Valentinus and Yulianti, Trilis and Notopuro, Paulus Budi Notopuro and Humardani, Farizky Martriano (2023) Genetic Polymorphisms of Ischemic Stroke in Asians. Clinica Chimica Acta, 549. 117527/1-12. ISSN 0009-8981; E-ISSN 1873-3492

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Abstract

The increasing incidence of ischemic stroke emphasizes the necessity for early detection and preventive stra- tegies. Diagnostic biomarkers currently available for ischemic stroke only become detectable shortly before the manifestation of stroke symptoms. Genetic variants associated with ischemic stroke offer a potential solution to address this diagnostic limitation. However, it is crucial to acknowledge that genetic variants cannot be modified in the same way as epigenetic changes. Nevertheless, individuals carrying risk or protective variants can modify their lifestyle to potentially influence the associated epigenetic factors. This study aims to summarize specific variants relevant to Asian populations that may aid in the early detection of ischemic stroke and explore their impact on the disease’s pathophysiology. These variants give us important information about the genes that play a role in ischemic stroke by affecting things like atherosclerosis pathway, blood coagulation pathway, homo- cysteine metabolism, transporter function, transcription, and the activity of neurons regulation. It is important to recognize the variations in genetic variants among different ethnicities and avoid generalizing the pathogenesis of ischemic stroke.

Item Type:	Article
Uncontrolled Keywords:	Asian; Early detection; Ischemic stroke; Pathways; Variants
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medical
Depositing User:	Ester Sri W. 196039
Date Deposited:	14 Sep 2023 02:04
Last Modified:	14 Sep 2023 07:45
URI:	http://repository.ubaya.ac.id/id/eprint/44925

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