GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults

Kalajanti, Viskasari P. and Wahjudi, Mariana and Purwantari, Kusuma Eko and Visuddho, Visuddho and Nawangsasi, Peppy and Oktariza, Rury T. and Pradana, Krisnawan Andy and Rahmawan, Dzanuar and Suwito, Bambang E. (2023) GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults. Jurnal ners, 18 (1). pp. 70-77. ISSN 1858-3598; e-ISSN 2502-5791

PDF Mariana Wahjudi_GABRA6 and SLC6A4 genotypes.pdf Download (3MB)

Abstract

Introduction: We examined environmental and genetic factors potentially correlated with the blood glucose and physical fitness in Kediri, East Java, Indonesia to elucidate the predominant cardiovascular disease risk.Methods:This was a cross-sectional study on 68 adults aged 18-22 years. Direct interview was conducted to get socio-economy, daily diets (rice/ R, snacks and sweets/ SS, veggies and fruits/ VF), daily activity (locomotors and non-locomotors) data. Peripheral blood-GABRA6 and SLC6A4 polymorphisms, fasting blood glucose (FBG), blood pressure, 3 fitness parameters (1 min push-up, 3 minutes step up, pulse rate after 3 minutes step-up) were measured by 2 independent and pre-trained medical doctors. Kruskal-Wallis, Chi-Square, andeta-coefficient tests were used to seek differences between genotypes and correlation strength between variables, respectively (significant if p<0.05).Results:Both gene’s genotypes showed significant correlations with the FBG (p=0.042, p=0.013, respectively); GABRA6 polymorphism significantly correlated with SU (p=0.033). There was a significant difference in the FBG between 2 VF subgroups (p=0.02). Strongest association was found between FBG and SLC6A4 (η=0.3); PR and GABRA6 (η=0.168), PU and SLC6A4 (η=0.38); SU and Locomotors (η=0.237).Conclusions:In these seemingly healthy young adults, daily diets and the genotypes of both genes have a good association with the FBG and physical fitness levels.

Item Type:	Article
Uncontrolled Keywords:	diabetes mellitus, fitness, GABA, health risk, serotonin
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	Ester Sri W. 196039
Date Deposited:	04 Oct 2023 08:14
Last Modified:	04 Oct 2023 08:15
URI:	http://repository.ubaya.ac.id/id/eprint/45045

Actions (login required)

View Item