Predictors of the Use of Amlodipine Monotherapy as the First Line Agent in the Treatment of Ambulatory Preeclampsia

Yana, Anna Ulfa and Brata, Cecilia and Irawati, Sylvi (2023) Predictors of the Use of Amlodipine Monotherapy as the First Line Agent in the Treatment of Ambulatory Preeclampsia. In: ACSA 2023, 14-15 Oktober 2023, Surabaya. (Submitted)

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Abstract

Background Preeclampsia has contributed to the high rate of maternal mortality in Indonesia. It has been reported that amlodipine is frequently used as one of the first line agents to manage preeclampsia in an outpatient setting. There have been some uncertainties around the efficacy and safety of amlodipine in pregnant women with hypertension, including in preeclampsia. Moreover, some relevant guidelines have encouraged to use nifedipine or methyldopa as the first line agent for this case. Objective This study aimed to investigate the predictors of the use of amlodipine as the first line agent for preeclampsia in an outpatient setting in Surabaya. Methods This is a cross-sectional study using data from medical records of pregnant women diagnosed with preeclampsia at an outpatient setting in one of children and maternal hospitals in Surabaya. Pregnant women who visited the setting during the period of January 1 to December 31, 2021 and met the inclusion criteria were included in the study. Potential predictors were baseline characteristics of pregnant women when they were first diagnosed with preeclampsia at the outpatient setting. The population of the study were divided into two groups (amlodipine vs nifedipine/methyldopa) and the predictors were compared between the groups. To confirm the predictors of the use of amlodipine to treat preeclampsia, a multivariate analysis was used. We present adjusted odds ratio and 95% confidence intervals for the predictors. All statistical analyses were done using SPSS version 26.0 with p-value ≤ 0.05 (two sided) as a cut-off for a statistically significant result. Results There were 168 pregnant women who met the inclusion criteria for this study, 67.9% of whom were prescribed with amlodipine. The significant predictor for the use of amlodipine was only baseline systolic blood pressure (adjusted odds ratio 0.934; 95% CI 0.893 – 0.977, p = 0.003). Conclusion Systolic blood pressure at baseline is the sole predictor that has been statistically significant for the use of amlodipine as the first line agent to treat preeclampsia. Studies to investigate the effectiveness and safety of amlodipine compared to other first line agents recommended by the guideline is needed.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Sylvi Irawati, M.Farm., Apt. 208004
Date Deposited:	23 Oct 2023 02:49
Last Modified:	23 Oct 2023 02:49
URI:	http://repository.ubaya.ac.id/id/eprint/45149

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