The Use of Statins in Primary Prevention of Cardiovascular Disease: Benefits versus Risks

Setiadi, Antonius Adji Prayitno and Irawati, Sylvi and Presley, Bobby and Setiawan, Eko and Wibowo, Yosi Irawati (2022) The Use of Statins in Primary Prevention of Cardiovascular Disease: Benefits versus Risks. World Heart Journal, 14 (2). pp. 129-138. ISSN 1556-4002

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Abstract

Background: Cardiovascular disease (CVD) remains a major global health issue. The use of statins in people with a history of CVD is generally well established, however, debate remains about their use for primary prevention in people without CVD. This narrative review aims to present studies related to the benefits and risks of taking statins for primary prevention of CVD. An internet search of the Cochrane Library (2006 to 2021) and PubMed (2006 to 2021) used the following keywords: Hydroxymethylglutaryl-CoA Reductase Inhibitors, statin OR statins; cardiovascular disease, heart disease, coronary disease; primary prevention. Systematic review/ meta- analyses-based articles were included in the review. The studies reported positive outcomes of statins, particularly in relation with reduction in all-cause mortality, non- fatal MI, and non-fatal stroke. Some adverse events were also reported, such as muscle problems, diabetes, liver dysfunctions, and renal and eye disorders, However, the risks attributable to statins were considerably lower and thus did not outweigh the benefits in preventing CVD. It should be acknowledged that the decision to initiate statins for primary prevention should not solely depend on the LDL-C value, but also on overall CVD risk factors for a particular individual, as can be seen in three major guidelines from the American College of Cardiology/ American Heart Association (ACC/AHA) - 2019, Canadian Society of Cardiology (CCS) - 2021, and the European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) - 2019. The risks attributable to statins were relatively low, and thus did not outweigh the benefits in preventing CVD.

Item Type:	Article
Uncontrolled Keywords:	statin, primary prevention, cardiovascular risk factor, cardiovascular disease
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Postgraduate Programs > Master Program in Clinical Pharmacy
Depositing User:	Yosi Irawati Wibowo 202026
Date Deposited:	18 Dec 2023 04:23
Last Modified:	18 Dec 2023 07:25
URI:	http://repository.ubaya.ac.id/id/eprint/45528

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