Investigating Methyl And Nitro Substituents Affect In Para Position On N-Benzoyl-N'- Phenylthiourea Compounds As Potential Treatments For Breast Cancer

Kesuma, Dini and Risthanti, Reine Risa and Sumartha, I Gede Ari (2023) Investigating Methyl And Nitro Substituents Affect In Para Position On N-Benzoyl-N'- Phenylthiourea Compounds As Potential Treatments For Breast Cancer. RASĀYAN Journal of Chemistry (RJC), 16 (4). pp. 2333-2339. ISSN 0974-1496; E-ISSN 0976-0083

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Abstract

The primary challenge in chemotherapy for breast cancer stems from the limited effectiveness of existing drugs due to the diverse mutations, each requiring specific treatment. Consequently, it is essential to focus on the development of drugs specifically designed for anti-breast cancer therapy. In this investigation, we synthesized and evaluated compounds with methyl and nitro substituents on the para position in N-benzoyl- N'-phenylthiourea to examine their efficacy against breast cancer cells (MCF-7). Computational analyses demonstrated favorable interactions with EGFR, and experimental tests revealed IC50 values of 0.42 mM for the first compound and 0.07 mM for the second compound. Remarkably, the second molecule showed enhanced selectivity and cytotoxicity (SI value of 937.57) in comparison to the first compound, suggesting that it could be a promising drug for the treatment of breast cancer.

Item Type:	Article
Uncontrolled Keywords:	Molecular Docking, Breast Cancer, EGFR, Phenylthiourea, Cytotoxic Activity
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	03 Jan 2024 08:58
Last Modified:	03 Jan 2024 08:58
URI:	http://repository.ubaya.ac.id/id/eprint/45600

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