Rani, Karina Citra and Prameswari, Paramitha and Matulatan, Cheryl and Setiawan, Finna and Jayani, Nikmatul Ikhrom Eka (2023) Development and Characterization of Surface Solid Dispersion Moringa oleifera Leaf Extract Microcrystalline Cellulose by Co-Grinding Method. In: International Conference on Contemporary Science and Clinical Pharmacy 2023 (ICCSCP2023), 30-31 October 2023, Faculty of Pharmacy, Universitas Andalas.
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Abstract
The extract of Moringa oleifera leaves contain flavonoid compounds which are potential antioxidant source. The development of Moringa oleifera leaf extract into an herbal product is still limited because of the difficulty in handling the consistency, hygroscopicity, and low solubility of the extract. Surface solid dispersion (SSD) is a versatile method to improve not only the physical characteristics but also the solubility of the extract. This study aimed to improve the characteristics of Moringa oleifera leaf extract through SSD using microcrystalline cellulose as a carrier. The preparation of the SSD was conducted by co-grinding method at two ratios of extract and carrier (1:2 and 1:4). The results of this study revealed that SSD was able to entrap the extract in the surface area of microcrystalline cellulose. Hence, the SSD powder performed better moisture content and flowability. The characterization of thermal characteristics and crystallinity also performed the reduction of crystal lattice regularity compared to the pure extract. It was observed from the reduction of enthalpy and distinctive peak intensity. The total flavonoid content of SSD 1:2 was 14.70±0.35 mg QE/g, whereas SSD 1:4 was 7.00±0.07 mg QE/g. The solubility of the flavonoid compound from SSD 1:2 was 62.26±0.62 ppm, while the solubility of SSD 1:4 was 63.58±0.62 ppm. The solubility of the flavonoid compound from SSD preparation increased about 1.16-fold compared to the physical mixture. The SSD powder with 1:2 and 1:4 ratios showed IC50 values of 539.38 ppm and 524.44 ppm respectively. The preparation of SSD of Moringa oleifera leaf extract can improve the physical and chemical characteristics of the extract before formulation.
| Item Type: | Conference or Workshop Item (Other) |
|---|---|
| Uncontrolled Keywords: | Moringa oleifera leaf extract, microcrystalline cellulose, surface solid dispersion, co-grinding |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | KARINA CITRA RANI |
| Date Deposited: | 08 Jan 2024 02:53 |
| Last Modified: | 08 Jan 2024 02:53 |
| URI: | http://repository.ubaya.ac.id/id/eprint/45620 |
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